Endocrine Abstracts

Neuroendocrine neoplasms (NENs) are rare but diverse group of malignancies that can arise from gastroenteropancreatic tract and lungs. NENs can be clinically symptomatic (functioning) or silent (non-functioning). We present a case found to have multiple NENs in the absence of known clinical syndrome and discuss role of genetic testing versus clinical screening. 54 Female, referred to endocrine team for investigation of hypoglycaemic symptoms and suspected insulinoma. Routine b...

Introduction: Immunotherapy has transformed the outcomes of various cancers. Monoclonal antibodies against cytotoxic T lymphocyte antigen 4 (CTLA4), programmed cell death 1 (PD1) and its ligand, PDL1 target mainly T cells, unleashing the immune system against tumour cells. Immune checkpoint inhibitor therapy results in a variety of immune related adverse events, including various endocrinopathies. Thyroid disorders, pituitary disorders are relatively more common compared to pr...

Introduction: Pituitary metastases (PM) are an uncommon manifestation of Neuroendocrine neoplasms (NENs) and are rarely reported. We report two cases of PM with different clinical lessons.Case 1: A 37-year-old female underwent surgical resection for a high grade poorly differentiated neuroendocrine carcinoma of the cervix (Ki67 90%). Serial follow-up surveillance assessments revealed disease progression (local, liver, lung, and bone) for which she underw...